Abstract
Sesquiterpene esters are the active principle in the medicinal plant Petasites hybridus. Two chemotypes, the petasin chemotype and the furanopetasin chemotype, are known,
but only the first one is suitable for pharmaceutical purposes. Experimental crossings
were performed within and between plants of both chemotypes to study the genetic basis
of the occurrence of these sesquiterpenes. The chemotype was determined by TLC in
extracts of a small piece of rhizome in the parent plants and the progenies. A model
including the combined action of two genes is proposed to explain the inheritance
of the chemotypes where the furanopetasin chemotype is under recessive genetic control.
References
- 1 Meier B, Meier-Liebi M. Petasites. In: Hänsel R, Keller K, Rimpler H, Schneider
G, editors
Hagers Handbuch der Pharmazeutischen Praxis. 5th edition, Vol 6 Berlin Heidelberg; Springer Verlag 1994: p 81-105
- 2 Barrett M. The handbook of clinically tested herbal remedies. Binghampton; Haworth
Herbal Press 2004: p 213-23
- 3
Wildi E, Langer T, Schaffner W, Berger Büter K.
Quantitative analysis of petasin and pyrrolizidine alkaloids in leaves and rhizomes
of in situ grown Petasites hybridus plants.
Planta Med.
1998;
64
264-7
- 4
Novotny L, Toman J, Stary F, Marquez A D, Herout V, Sorm F.
Contribution to the chemotaxonomy of some European Petasites species.
Phytochemistry.
1966;
5
1281-7
- 5
Debrunner B, Neuenschwander M, Brenneisen R.
Sesquiterpenes of Petasites hybridus (L.) G.M. et Sch.: distribution of sesquiterpenes over plant organs.
Pharm Acta Helv.
1995;
70
167-73
- 6
Debrunner B, Neuenschwander M.
Sesquiterpenes of Petasites hybridus (L.) G.M. et Sch.: influence of locations and seasons on sesquiterpene distribution.
Pharm Acta Helv.
1995;
70
315-23
- 7 Siegenthaler P. Untersuchungen zur Struktur und Analytik der Inhaltsstoffe von Petasites albus und Petasites hybridus (Furanopetasin-Chemovarietät) [dissertation]. Bern; University of Bern 1995
- 8
Chizzola R, Ozlsberger B, Langer T.
Variability in chemical constituents in Petasites hybridus from Austria.
Biochem Syst Ecol.
2000;
28
421-32
- 9
Vetter S, Franz C, Glasl S, Kastner U, Saukel J, Jurenitsch J.
Inheritance of sesquiterpene lactone types within the Achillea millefolium complex (Compositae).
Plant Breed.
1997;
116
79-82
- 10
Franz C, Wickel J.
Zur Vererbung der Bestandteile des Kamillenöls. 1. Mitt.: Qualitative Vererbung von
Chamazulen und (-)-α-Bisabolol.
Herba Hung.
1985;
24
49-59
- 11
Horn W, Franz C, Wickel I.
Genetics of bisaboloids in chamomile.
Plant Breed.
1988;
101
307-12
- 12
Thompson J D, Chalchat J C, Michet A, Linhart Y B, Ehlers B.
Qualitative and quantitative variation in monoterpene co-occurrence and composition
in the essential oil of Thymus vulgaris chemotypes.
J Chem Ecol.
2003;
29
859-80
- 13
Chizzola R, Langer T.
Distribution of pyrrolizidine alkaloids in crossing progenies of Petasites hybridus
.
J Herbs Spices Med Plants.
2002;
9
39-44; As book chapter in: Johnson CB, Franz C, editors. Breeding research on aromatic
and medicinal plants. New York: Haworth Press; 2002. p 39 - 44
- 14
Debrunner B, Meier B.
Petasites hybridus: A tool for interdisciplinary research in phytotherapy.
Pharm Acta Helv.
1998;
72
359-80
- 15 Wagner H, Bladt S. Plant drug analysis. A thin layer chromatography atlas. 2nd
edition Berlin; Springer 1996: p 359
Dr. Remigius Chizzola
Institute for Applied Botany and Pharmacognosy
Department of Veterinary Public Health
University of Veterinary Medicine Vienna, Austria
Veterinaerplatz 1
1210 Vienna
Austria
Telefon: +43-1-25077-3104
Fax: +43-1-25077-3190
eMail: Remigius.Chizzola@vu-wien.ac.at
