Planta Med 2006; 72 - P_141
DOI: 10.1055/s-2006-949941

Soyabean Lipoxygenase Inhibitory Activity of Flavonoids, Phenylethanoid glycosides and phenolic acids from Marrubium velutinum and M. cylleneum

A Karioti 1, D Hadjipavlou-Litina 2, H Skaltsa 1
  • 1Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, Panepistimiopolis-Zografou, 15771 Athens, Greece
  • 2Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, 54124, Greece

Marrubium sp. are widely used in traditional medicine in Greece in cases of inflammatory, bronchial, stomach diseases, coughs and catarrhs of the respiratory tract.

In previous papers, we reported the isolation and identification of secondary metabolites from the methanol extracts from the aerial parts of M. velutinum Sm. and M. cylleneum Boiss. et Heldr. [1, 2]. In a continuation of our chemical and biological investigations on Marrubium species of the Greek flora, we studied the isolated phenolic compounds in vitro for their interaction with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radical and for their inhibitory activity against soybean lipoxygenase. The conversion of sodium linoleate to 13-hydroperoxylinoleic acid at 234 nm was recorded and compared with the appropriate standard inhibitor. The initial methanol extracts and 25 secondary metabolites have been tested. Phenylethanoid glycosides were found to be active.

References: 1 Michelis, F., Tiligada, E. et al. (2002), Pharm. Biol. 40: 245–248. 2. Karioti, A. et al. (2003), Phytochemistry 64: 655–660.