Efficient Oxidative Synthesis of 2-Oxazolines

Abstract

New methodology for the synthesis of variously substituted 2-oxazolines and one dihydrooxazine using aldehydes, amino alcohols, and N-bromosuccinimide as an oxidizing agent is described. This one-pot synthesis is characterized by mild reaction conditions, broad scope, high yields, and its preparative simplicity.

Key words

amino alcohols - oxidative coupling - oxazolines - oxazolidines - N-bromosuccinimide

References

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15

This work was first presented on the BASF Catalysis Award Symposium, in Heidelberg, Germany, July 8 2005.

17

More highly substituted amino alcohols have not been tested.