Ischämische Prä- und Postkonditionierung

Zusammenfassung

Ein oder mehrere kurze Zyklen von Ischämie/Reperfusion kurz vor (Präkonditionierung) oder nach (Postkonditionierung) einem längerdauernden Koronarverschluss mit anschließender Reperfusion reduzieren die Infarktgröße. Die protektive Wirkung ist potent, aber auf einen engen zeitlichen Rahmen beschränkt. Im Experiment wurde eine komplexe Signaltransduktionskaskade identifiziert, die letztlich spezifisch den Reperfusionsschaden reduziert. Belege für ischämische Prä- und Postkonditionierung gibt es auch bei Patienten mit koronarer Herzkrankheit.

Summary

One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury. There is evidence for both ischemic pre-and postconditioning in patients with coronary artery disease.

Schlüsselwörter

Myokardinfarkt - Reperfusionsschaden - ischämische Präkonditionierung - ischämische Postkonditionierung

Key words

myocardial infarction - reperfusion injury - ischemic preconditioning - ischemic postconditioning

Literatur

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