Inhibitory Activity of Phenolic Glycosides from the Fruits of Idesia polycarpa on Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia

Abstract

Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-β-D-glucopyranosyl-(6→1)-α-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of Idesia polycarpa. All six compounds significantly inhibited lipopolysaccharide-induced nitric oxide production in BV2 microglia at concentrations from 1 μM to 100 μM.

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