A Comparative Study of the Analgesic and Anti-Inflammatory Activities of Pectolinarin Isolated from Cirsium subcoriaceum and Linarin Isolated from Buddleia cordata

Mariano Martínez-Vázquez; Teresa O. Ramírez Apan; Ana Lilia Lastra; Robert Bye

doi:10.1055/s-2006-957390

Planta Medica, Table of Contents

Planta Med 1998; 64(2): 134-137
DOI: 10.1055/s-2006-957390

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

A Comparative Study of the Analgesic and Anti-Inflammatory Activities of Pectolinarin Isolated from Cirsium subcoriaceum and Linarin Isolated from Buddleia cordata

Mariano Martínez-Vázquez¹ , Teresa O. Ramírez Apan¹ , Ana Lilia Lastra¹ , Robert Bye²

¹Instituto de Química, Universidad Nacional Autónoma de México, Coyoacán, México
²Jardín Botánico, Instituto de Biología, Universidad Nacional Autónoma de México, Coyoacán, México

Abstract

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Abstract

The dried aqueous extract of aerial parts of Cirsium subcoriaceum (Asteraceae) and its major flavonoid glycoside, pectolinarin, have been evaluated for analgesic and anti-inflammatory effects in mice and rats, respectively. Both the extract and pectolinarin exerted significant and dose-dependent analgesic and anti-inflammatory activities. Also, the anti-inflammatory activities of an aqueous extract of Buddleia cordata and its principal glycoside linarin were evaluated. The results of pharmacological testing proved that linarin is a better anti-inflammatory agent than pectolinarin and indomethacin. On the other hand, pectolinarin exerted a better analgesic effect than linarin.

Key words

Cirsium subcoriaceum - Buddleia cordata - flavone - pectolinarin - linarin - analgesic - anti-inflammatory

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