Abstract
The anti-inflammatory and related activities of bukittinggine were evaluated in comparison
with reference drugs. The results obtained revealed that bukittinggine exhibited a
significant inhibitory effect in carrageenin-induced hind paw edema and adjuvant-induced
arthritis in rats. Its anti-inflammatory activity in both test models was comparable
to that of acetylsalicylic acid. Bukittinggine also showed an inhibitory effect on
the late proliferative phase of the inflammatory process in cotton pellet-induced
granuloma formation in rats. In carrageenin-induced rat pleurisy, bukittinggine exhibited
marked inhibitory activity on exudative formation, accumulation of leukocytes and
on PGE2-like activity in the exudate. Furthermore bukittinggine could significantly reduce
fever in yeast-induced hyperthermic rats and possessed analgesic activity comparable
to that of acetylsalicylic acid when tested in acetic acid-induced writhing response
in mice. However, bukittinggine exhibited only a weak effect in the tail-flick test
when compared with morphine. It is likely that bukittinggine possesses a mechanism
of anti-inflammatory, analgesic and antipyretic action similar to that of acetylsalicylic
acid.
Key words
Anti-inflammatory - analgesic and antipyretic activity -
Sapium baccatum
- Euphorbiaceae - bukittinggine
