A New Bioactive Norquinone-Methide Triterpene from Maytenus scutioides

A. G. González; N. L. Alvarenga; I. L. Bazzocchi; A. G. Ravelo; L. Moujir

doi:10.1055/s-2006-957581

Planta Medica, Table of Contents

Planta Med 1998; 64(8): 769-771
DOI: 10.1055/s-2006-957581

Letters

A New Bioactive Norquinone-Methide Triterpene from Maytenus scutioides

A. G. González¹ , N. L. Alvarenga¹ , I. L. Bazzocchi¹ , A. G. Ravelo¹ , L. Moujir²

¹Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Tenerife, Canary Islands, Spain
²Departamento de Microbiología y Biología Celular, Universidad de La Laguna, La Laguna, Tenerife, Canary Islands, Spain

Abstract

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Abstract

By antimicrobial and cytotoxic-guided fractionation, a bioactive norquinone-methide triterpene, 15α-hydroxypristimerin, was isolated from a South American medicinal plant, Maytenus scutioides. Its structure was determined on the basis of spectroscopic evidence. Successful chemical transformation of pristimerin to netzahualcoyene indicates that the 15-hydroxy compounds seems to be a possible precursor of 14(15)-ene-quinone-methide-triterpenoids in the biogenetic pathway.

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