Ginseng Total Saponin Inhibits the Dopaminergic Depletions Induced by Methamphetamine

Ki-Wan Oh; Hack-Seang Kim; George C. Wagner

doi:10.1055/s-2006-957610

Planta Medica, Inhaltsverzeichnis

Planta Med 1997; 63(1): 80-81
DOI: 10.1055/s-2006-957610

Letters

Ginseng Total Saponin Inhibits the Dopaminergic Depletions Induced by Methamphetamine

Ki-Wan Oh¹ , Hack-Seang Kim¹ , George C. Wagner²

¹Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea
²Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, U.S.A.

Abstract

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Abstract

Pretreatment with ginseng total saponin (GTS) reduced the magnitude of the methamphetamine-induced dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillinic acid (HVA) depletions. It is suggested that GTS can, in part, prevent the methamphetamine-induced striatal dopaminergic depletions.

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