Konishiol, A New Sesquiterpene, and Bioactive Components from Cunninghamia konishii

Kan He; Guoen Shi; Lu Zeng; Qing Ye; Jerry L. McLaughlin

doi:10.1055/s-2006-957635

Planta Medica, Table of Contents

Planta Med 1997; 63(2): 158-160
DOI: 10.1055/s-2006-957635

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Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Konishiol, A New Sesquiterpene, and Bioactive Components from Cunninghamia konishii

Kan He, Guoen Shi, Lu Zeng, Qing Ye, Jerry L. McLaughlin

Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, U.S.A

Abstract

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Abstract

Three sesquiterpenes, konishiol (1), cadalenol (2), 3-cedranol (3), one diterpene, manool (4), and one lignan, (+)-tsugacetal (5), have been isolated, for the first time, from the whole plant of Cunninghamia konishii by using bioactivity-directed fractionation. Compound 1 is new to the literature, and its chemical structure was determined by various spectroscopic analyses including EIMS, HREIMS, NOE, NOESY, and by preparing its di-acetyl derivative (la). Compounds 2-5 showed moderate to weak bioactivities in brine shrimp (BST) and mosquito larvae (YFM) bioassays as well as cytotoxicities against three human solid tumor cell lines.

key words

Cunninghamia konishii - Pinaceae - sesquiterpenes - konishiol - cytotoxic activity

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