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Planta Med 1997; 63(2): 171-176
DOI: 10.1055/s-2006-957638
Papers
Phytochemical Analysis
© Georg Thieme Verlag Stuttgart · New York

An Analytical Study and Anti-Inflammatory and Analgesic Effects of Harpagophytum procumbens and Harpagophytum zeyheri

B. Baghdikian1 , M. C. Lanhers2 , J. Fleurentin3 , E. Ollivier1 , C. Maillard1 , G. Balansard1 , F. Mortier4
  • 1Laboratory of Pharmacognosy, Faculty of Pharmacy, 27, Bd jean Moulin, F-13385 Marseille Cedex 5, France
  • 2Laboratory of General Chemistry, Faculty of Medicine, BP 184, F-54505 Vandoeuvres les Nancy, France
  • 3Laboratory of Ethnobotany, University of Metz, CSE, 1, rue des Recollets, F-57000 Metz, France
  • 4Laboratory of Pharmacognosy, Faculty of Pharmacy, 5, rue Albert lebrun, F-54000 Nancy, France
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1996

1996

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

The iridoids of Harpagophytum procumbens and Harpagophytum zeyheri were studied by CLHP. Harpagoside is the main iridoid for both drugs whereas 8-p-coumaroylharpagide is a representative iridoid of Harpagophytum zeyheri only. The ratio harpagoside/8-p-coumaroylharpagide can be used to distinguish chemically both species. For commercial dried aqueous extracts this ratio is intermediate because they are probably prepared from a mixture of H. procumbens and H. zeyheri drugs. The aqueous extracts of both drugs show similar analgesic and anti-inflammatory properties. Harpagophytum procumbens and Harpagophytum zeyheri should be accepted as sources for the drug Harpagophyti radix.

key words

Harpagophytum procumbens - Harpagophytum zeyheri - Pedaliaceae - harpagoside - 8-p-coumaroylharpagide - anti-inflammatory activity - analgesic activity

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