Abstract
Oxygen radical injury and lipid peroxidation have been suggested as major causes of
atherosclerosis, cancer, liver disease, and the aging process. More specifically,
oxidative modification of low density lipoprotein (LDL) has been recognized as an
important process of atherosclerosis. In this study, we determined the effects of
aged garlic extract (AGE), four of its constituents, and a metabolite on Cu2+-induced oxidative modification of LDL using an in vitro system. All these compounds were shown to inhibit oxidative modification of LDL
