Cytotoxic Sterols from the Formosan Brown Alga Turbinaria ornata

Jyh-Horng Sheu; Guey-Horng Wang; Ping-Jyun Sung; Yen-Hung Chiu; Chang-Yih Duh

doi:10.1055/s-2006-957772

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Planta Med 1997; 63(6): 571-572
DOI: 10.1055/s-2006-957772

Letters

Cytotoxic Sterols from the Formosan Brown Alga Turbinaria ornata

Jyh-Horng Sheu, Guey-Horng Wang, Ping-Jyun Sung, Yen-Hung Chiu, Chang-Yih Duh

Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, R.O.C.

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1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

Two hydroperoxysterols 24-hydroperoxy-24-vinyl-cholesterol (1) and 29-hydroperoxystigmasta-5,24(28)-dien-3β-ol (2), and fucosterol (3) were isolated from the brown alga Turbinaria ornata (Sargassaceae). Hydroperoxide 2 is a new natural compound and was converted into 29-hydroxystigmasta-5,24 (28)-dien-3β-ol (4) by reaction with LAH. Sterols 1, 2, and 4 exhibited cytotoxicity against various cancer cell lines.