Comparison of Antimicrobial Properties of Monoterpenes and their Carbonylated Products

Ruth Naigre; Philippe Kalck; Christine Roques; Isabelle Roux; Georges Michel

doi:10.1055/s-2006-957877

Planta Medica, Table of Contents

Planta Med 1996; 62(3): 275-277
DOI: 10.1055/s-2006-957877

Letter

Comparison of Antimicrobial Properties of Monoterpenes and their Carbonylated Products

Ruth Naigre¹ , Philippe Kalck¹ , Christine Roques² , Isabelle Roux² , Georges Michel²

¹Laboratoire de Chimie des Procédés, Ecole Nationale Supérieure de Chimie de Toulouse, 118, route de Narbonne, F-31077 Toulouse Cédex, France
²Laboratoire de Bactériologie, Virologie et Microbioiogie industrielle, Université Paul Sabatier, Faculté de Pharmacie, 35 chemin des Maraîchers, F-31062 Toulouse Cedéx, France

Abstract

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Abstract

Some monoterpenes and their carbonylated products were evaluated for their antibacterial and antifungal properties. The carbonylation of tested monoterpenes was shown to increase the bacteriostatic and fungistatic activities specifically by the contact method. Concerning the killing effects, only (1R,2S,5R)-isopulegol, its carbonylated product, and (R)-carvone showed significant bactericidal activities, particularly against Enterococcus faecium and Escherichia coli above a concentration of 10 µl/ml. A fungicidal efficiency of (1R,2S,5R)-isopulegol and (R)-carvone against Aspergillus niger was also noted. It seems that the presence of an oxygenated function in the framework increases the antimicrobial properties. However, monoterpenes were more active using a micro-atmosphere method.

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