Planta Medica, Table of Contents Planta Med 1995; 61(5): 406-408DOI: 10.1055/s-2006-958125 Paper © Georg Thieme Verlag Stuttgart · New YorkEmodin Pharmacokinetics in RabbitsJ. W. Liang1 , S. L. Hsiu2 , P. P. Wu2 , P. D. L. Chao 1Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan, Republic of China 2School of Pharmacy, China Medical College, Taichung, Taiwan, Republic of China Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Abstract Administration of emodin to rabbits by i.v. bolus resulted in a serum profile which could be well described by a two-compartment model. The AUC of emodin was 518 µg · min/ml, clearance was 72.3 ml/min, and elimination half life was 227 min which was much longer than that reported in a previous study. Oral administration of emodin resulted in a very low serum concentration. Protein binding of emodin was investigated by the equilibrium dialysis method. Emodin was found to be highly bound (99.6%) to serum protein. Key words Anthraquinone - emodin - pharmacokinetics PDF (212 kb)
