Synfacts 2007(2): 0163-0163  
DOI: 10.1055/s-2006-958968
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rh-Catalyzed Synthesis of Alkenylphosphines

Contributor(s): Mark Lautens, Yann Béthuel
M. Hayashi*, Y. Matsuura, Y. Watanabe
Ehime University, Matsuyama, Japan
Further Information

Publication History

Publication Date:
23 January 2007 (online)

Significance

In the present paper, the authors report on the selective synthesis of organophosphorous compounds. The reaction proved to be quite general as alkyl- and aryl-substituted terminal and internal alkynes are efficiently transformed into syn-hydrophosphinated products. Functionalities such as alcohols and esters are tolerated under the reaction conditions. Moreover, the effectiveness of this methodology was further demonstrated by efficiently transforming activated alkenes into β-phosphinopropionic acid derivatives.