Sesquiterpene Lactones and Inositol Esters from Arnica angustifolia1,*

Thomas J. Schmidt; Günter Willuhn; Alois Steigel; Detlef Wendisch

doi:10.1055/s-2006-959368

Planta Medica, Inhaltsverzeichnis

Planta Med 1995; 61(6): 544-550
DOI: 10.1055/s-2006-959368

Papers

Sesquiterpene Lactones and Inositol Esters from Arnica angustifolia ^1,*

Thomas J. Schmidt¹ ^, ² , Günter Willuhn² , Alois Steigel³ , Detlef Wendisch⁴

²Institut für Pharmazeutische Biologie der Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany
³Institut für Organische Chemie der Heinrich-Heine Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany
⁴Bayer-AG, Abt. ZF-D Strukturforschung, D-51368 Leverkusen, Germany

1 Part of a dissertation (1). Preliminary reports of this work were presented at the 10th Annual Meeting of the ÖPhG, Vienna 1992 (2) and at the 41st Annual Congress of the Society for Medicinal Plant Research, Düsseldorf 1993 (3)* Dedicated to Professor Dr. Horst Rimpler, Freiburg, on the occasion of his 60th birthday.

Abstract

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Abstract

From flowerheads of Arnica angustifolia ssp. attenuata nine helenanolides, two 1,5-trans-guaianolides, and a mixture of inositol-tetraesters were isolated. Five of the helenanolides are described for the first time. One of them, 4-O-tigloylarnicalpin, is the first 7(12),6-trans-lactonized pseudoguaianolide isolated from a natural source. The occurrence of inositol esters within the genus Arnica has not been reported before.

Key words

Arnica angustifolia ssp. attenuata - Asteraceae - sesquiterpene lactones - pseudoguaianolides - helenanolides - guaianolides - inositol esters

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Sesquiterpene Lactones and Inositol Esters from Arnica angustifolia 1,*

Sesquiterpene Lactones and Inositol Esters from Arnica angustifolia ^1,*