Isolation, Structure and Synthesis of Conocurvone, a Potent, Novel HIV-Inhibitory Naphthoquinone Trimer from Conospermum Species

L. A. Decosterd; I. C. Parsons; K. R. Gustafson; J. H. Cardellina; J. McMahon; G. M. Cragg; Y. Murata; L. K. Pannell; J. R. Steiner; J. Clardy; M. Boyd

doi:10.1055/s-2006-959777

Planta Med 1993; 59: A581
DOI: 10.1055/s-2006-959777

Short Lectures

Isolation, Structure and Synthesis of Conocurvone, a Potent, Novel HIV-Inhibitory Naphthoquinone Trimer from Conospermum Species

L. A. Decosterd¹ ^, ⁵ , I. C. Parsons¹ , K. R. Gustafson¹ , J. H. Cardellina¹ II , J. McMahon¹ , G. M. Cragg² , Y. Murata³ , L. K. Pannell³ , J. R. Steiner⁴ , J. Clardy⁴ , M. Boyd¹

¹Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Programm, Division of Cancer Treatment, National Cancer Institute, Building 1052, Room 121, Frederick, MD 21702-1201, U.S.A.
²Natural Products Branch, DTP, NCI, Frederick, MD 21702-1201, U.S.A.
³Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD 20892, U.S.A.
⁴Department of Chemistry, Cornell University, Ithaca, NY 14853-1301, U.S.A.
⁵Division of Clinical Pharmacology, Department of Internal Medicine, BH-18, LAB 218, CHUV, CH-1011 Lausanne, Switzerland