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Planta Med 1991; 57(1): 25-28
DOI: 10.1055/s-2006-960009
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© Georg Thieme Verlag Stuttgart · New York

Picroliv Affords Protection Against Thioacetamide-Induced Hepatic Damage in Rats1

Yogesh Dwivedi, Ravi Rastogi, Sri Kant Sharma, Narendra Kumar Garg, Bhola Nath Dhawan
  • ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow-226 001, India
1 C.D.R.I. Communication No. 4556
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Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Thioacetamide (100 mg/kg), when administered to normal rats, caused a significant increase in the activities of 5′-nucleotidase and γ-glutamyl transpeptidase and a decrease in the activities of glucose 6-phosphatase and succinate dehydrogenase enzymes in the liver. DNA, RNA, and proteins were increased while the cytochrome P450 in the microsomal fraction and the glycogen content in the liver were decreased significantly. Elevations in the activities of GOT, GPT, and alkaline phosphatase and bilirubin content in serum were also observed. Picroliv, a standardised glycoside fraction of Picrorhiza kurroa, in doses of 12.5 and 25 mg/kg prevented most of the biochemical changes induced by thioacetamide in liver and serum. The hepatoprotective activity of Picroliv was comparable with that of silymarin, a known hepatoprotective agent obtained from seeds ofSilbum marianum.

Key words

Picrorhiza kurrooa - thioacetamide - silymarin - hepatotoxicity - hepatoprotection - Picroliv