A New Phloroglucinol Derivative from Hypericum calycinum with Antifungal and in vitro Antimalarial Activity1

Laurent A. Decosterd; Eberhard Hoffmann; Rolf Kyburz; Dorothy Bray; Kurt Hostettmann

doi:10.1055/s-2006-960203

Planta Medica, Table of Contents

Planta Med 1991; 57(6): 548-551
DOI: 10.1055/s-2006-960203

Papers

A New Phloroglucinol Derivative from Hypericum calycinum with Antifungal and in vitro Antimalarial Activity¹

Laurent A. Decosterd² , Eberhard Hoffmann³ , Rolf Kyburz³ , Dorothy Bray⁴ , Kurt Hostettmann²

²Institut de Pharmacognosie et Phytochimie, Ecole de Pharmacie, Université de Lausanne, CH-1015 Lausanne, Switzerland
³NMR Applications Laboratory, Varian GmbH, D-6100 Darmstadt, Federal Republic of Germany
⁴Department of Immunology, Royal Free Hospital of Medicine, Hampstead, London NW3 2Q6, U.K.

1 Presented in part at the 37th Congress of the Society of Medicinal Plant Research, Braunschweig, FRG, 5-9th September, 1989; Decosterd, L. A., Stoeckli-Evans, H., Chapuis, J.-C, Sordat, B., Hostettmann, K. (1989) Planta Med. 55, 629-630

Abstract

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Abstract

The new phloroglucinol derivative 1 has been isolated from the light petroleum ether extract of the aerial parts of Hypericum calycinum. Its structure has been established by means of ¹H- and ¹³C-NMR spectroscopy and by nOe, MHQC, and HMBC experiments on its monomethyl ether derivative 3. Compound 1 was fungicidal against Cladosporium cucumerinum in a TLC bioassay. In addition, this new phloroglucinol derivative was also found to exert an interesting antimalarial activity in an in vitro test system.

Key words

Hypericum calycinum - Cladosporium cucumerinum - phloroglucinol derivative - antifungal activity - antimalarial activity - Plasmodium falciparum

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