Planta Medica, Inhaltsverzeichnis Planta Med 1990; 56(2): 187-189DOI: 10.1055/s-2006-960922 Papers © Georg Thieme Verlag Stuttgart · New YorkA Novel Antibacterial Diterpene from Premna schimperi Solomon Habtemariam1 , Alexander I. Gray2 , Gavin W. Halbert3 , Peter G. Waterman2 1Department of Chemistry, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia 2Phytochemistty Research Laboratories, Department of Pharmacy, University of Strathclyde, Glasgow G1 1 XW, Scotland, U.K. 3Division of Pharmaceutics, Department of Pharmacy, University of Strathclyde, Glasgow G1 1 XW, Scotland, U.K. Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract A novel diterpene, (5R,8R,9S,10R)-12-oxo-ent-3,13(16)-clerodien-15-oic acid, has been obtained from the leaves of Premna schimperi (Verbenaceae) using an anti-microbial bioassay-guided isolation procedure. The diterpene was identified on the basis of spectroscopic data and is active against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis in the concentration range 20-25 µg ml-1. Key words Premna schimperi - Verbenaceae - novel clerodane diterpene - antibacterial activity PDF (239 kb)
