Recent Developments in the Biosynthesis of the Tropane Alkaloids1

Edward Leete

doi:10.1055/s-2006-960979

Planta Medica, Inhaltsverzeichnis

Planta Med 1990; 56(4): 339-352
DOI: 10.1055/s-2006-960979

Review

Recent Developments in the Biosynthesis of the Tropane Alkaloids¹

Edward Leete

Natural Products Laboratory, Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, U.S.A.

1 Presented in part at the 37th Annual Congress of the Gesellschaft für Arzneipflanzenforschung, September 5-9, 1989, Braunschweig, FRG

Abstract

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Abstract

Recent work on the biosynthesis of the tropane moiety of cocaine, hyoscamine, scopolamine, and related alkaloids is reviewed. Revision of the generally accepted biosynthetic pathway to these alkaloids is now proposed in the light of new discoveries. New information on the biosynthesis of some of the acid moieties (benzoic, tiglic and tropic acid) of the tropane ester alkaloids is also discussed.

Key words

Biosynthesis - tropane alkaloids - cocaine - hyoscyamine - scopolamine - tropane ester alkaloids

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