Planta Medica, Table of Contents Planta Med 1990; 56(4): 360-363DOI: 10.1055/s-2006-960982 Papers © Georg Thieme Verlag Stuttgart · New YorkEffect of Salvianolic Acid A, a Depside from Roots of Salvia miltiorrhiza, on Gastric H+, K+-ATPaseShigeru Murakami1 , Haruko Kijima1 , Yoshihiko Isobe1 , Makoto Muramatsu1 , Hironaka Aihara1 , Susumu Otomo1 , Li Liang-niang2 , Ai Chun-bo2 1Research Center, Taisho Pharmaceutical Co. Ltd., Ohmiya, Saitama 330, Japan 2Institute of Materia Medica, Chinese Academy of Medical Science, Beijing 100050, People's Republic of China Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Abstract Salvianolic acid A, a depside from the roots of Salvia miltiorrhiza, inhibited pig gastric H+,K+-ATPase and pNPPase with 50% inhibition values (IC50) of 5.2 × 10-7 M and 1.7 × 10-6 M, respectively. Kinetic studies revealed that the inhibition patterns induced by Salvianolic acid A were competitive with respect to ATP and noncompetitive with respect to K+. Salvianolic acid A (25 mg/kg, i.p.) significantly inhibited acid secretion in pylorus-ligated rats. At the same dose it also showed a significant reduction in the formation of gastric lesion induced by water immersion and restraint stress. These results suggest that Salvianolic acid A shows antisecretory and antiulcer activity by inhibiting the gastric H+,K+-ATPase. Key words H+, K+-ATPase - acid secretion - anti-ulcer - anti-secretory - salvianolic acid A - Salvia miltiorrhiza PDF (265 kb)
