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DOI: 10.1055/s-2006-961413
© Georg Thieme Verlag Stuttgart · New York
Time Course and Inhibition of Saponin-Induced Hemolysis
Publication History
1991
Publication Date:
05 January 2007 (online)

Abstract
Hemolytic activities of 3 steroid saponins reached plateaus within 5 min, whereas those of 4 triterpenoid saponins did not within 60 min. Erythrocytes pretreated with a low concentration of tigogenin were resistant to hemolysis of some of these saponins, but those pretreated with hecogenin or tomatidine were as sensitive as non-treated erythrocytes. Therefore, the ketone group of hecogenin or the amino group of tomatidine would weaken the interactions between the erythrocytes and these sapogenins. Furthermore, incubations of these saponins with a small amount of cholesterol diminished the hemolytic activities.
Key words
Hemolysis - time course - inhibition - saponin - sapogenin - cholesterol