Abstract
The anti-oxidant activity of nine dibenzocyclooctene lignans isolated from Schisandra chinensis, S. rubriflora, and Kadsura longipedunculata, respectively, was studied. Seven of the 9 lignans (1 mM) inhibited iron/cysteine-induced
lipid peroxidation (malondialdehyde, MDA, formation) of rat liver microsomes as well
as superoxide anion production in the xanthine/xanthine oxidase system. The actions
of the 7 lignans were much more potent than vitamin E at the same concentration of
1 mM. Among the lignans, schisanhenol was the most active one. This compound also
prevented the decrease of membrane fluidity of liver microsomes induced by iron/cysteine.
The results indicated that seven of the lignans such as schisanhenol have anti-oxidant
activities.
Key words
Schisandra chinensis
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Schisandra rubriflora
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Kadsura longipedunculata
- dibenzocyclooctene lignans - schisanhenol - lipid peroxidation - anti-oxidant activity
