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Planta Med 1987; 53(5): 444-449
DOI: 10.1055/s-2006-962770
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© Georg Thieme Verlag Stuttgart · New York

Die Steroidalkaloide von Funtumia africana 1

Steroid Alkaloids of Funtumia africana 1 H. Wagner2 , K. Seegert2 , H. Sonnenbichler3 , M. Ilyas4 , K. P. Odenthal5
  • 2Institut für pharmazeutische Biologie der Universität München, Karlsstraße 29, D-8000 München 2, Bundesrepublik Deutschland.
  • 3Max Planck Institut für Biochemie, Martinsried, München, Bundesrepublik Deutschland.
  • 4Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria.
  • 5Biologisches Laboratorium der Firma Madaus, D-5000 Köln, Bundesrepublik Deutschland.
1 6. Mitteilung über cardiotone Pflanzeninhaltsstoffe.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

From the stem bark of Funtumia africana (Benth.) Stapf three steroid alkaloids of the conanine-type were isolated. Two of them were identified as the new 12α-hydroxy norcona-N(18),1,4-trienin-3-one and 11α,12α-dihydroxy norcona-N(18),1,4-trienin-3-one, respectively. The third alkaloid proved to be identical with holonamine (i.e. 11α-hydroxy norcona-N(18),1,4-trienin-3-one), previously isolated from the stem bark of Holarrhena antidysenterica. Extracts of Funtumia africana showed a dose-related reduction of heart frequency as tested in in vivo and in vitro experiments and thus a similar pharmacological activity as extracts of the stem bark of Holarrhena antidysenterica.

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