Gansongon, ein neues Aristolan-Keton aus Nardostachys chinensis Batalin und Strukturrevision eines Aristolenols

Abstract

A new instable aristolane type sesquiterpene ketone, gansongone (1), was isolated from the fresh underground parts of Nardostachys chinesis Batalin (Valerianaceae), growing in the province Sichuan (China). The structure of 1 was elucidated by spectroscopic and chemical methods. The structure of the corresponding alcohol 2, which was also found in N. chinensis and formerly regarded as 9-aristolene-1α-ol (5) has to be revised to l(10)-aristolene-9β-ol (2) from results of 2D-NMR-spectroscopy and oxidation to 1. Besides 1 and 2, the following compounds have been identified in the ethanol extract of the fresh plant material of N. chinensis: nardosinone, nardosinondiol, deoxonarchinol A, β-sitosterol, oleanolic acid, ethyl β-D-glucopyranoside.