Summary
This study was planned to investigate whether the physiological variations in endogenous
gonadal steroid hormones during fertile period to menopause might affect the Arylsulphatase
A (ARS-A) activities in leukocytes in healthy women. In premenopausal women, means
of the leukocyte ARS-A activity were significantly highest at ovulatory phase, and
lowest at early follicular phase. In contrast, the mean leukocyte ARS-A activity in
postmenopausal women was approximataely equivalent to the mean leukocyte enzyme in
cycling women at early follicular phase in whom the lowest enzymatic activity was
observed. The results of our study, therefore, concluded that gonadal steroid released
physiologically into the bloodstream might be expected to stimulate the lysosomal
system thereby leading to an enhancement in leukocyte ARS-A activity.
Key words
- Arylsulphatase A - Gonadal Steroid Hormones - Sexual Steroids - Estradiol - Progesterone
- Leukocyte
