Long-Term Exposure to SMS 201-995 Inhibits Proliferation and Calcitonin Release in Neoplastic C-Cells

Yalemtsehay Mekonnen; F. Raue; A. Zink; R. Ziegler

doi:10.1055/s-2007-1002167

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1993; 25(10): 528-531
DOI: 10.1055/s-2007-1002167

Originals Basic

Long-Term Exposure to SMS 201-995 Inhibits Proliferation and Calcitonin Release in Neoplastic C-Cells

Yalemtsehay Mekonnen¹ , F. Raue² , A. Zink² , R. Ziegler²

¹Department of Biology, Faculty of Science, Addis Abeba University, Addis Abeba, Ethiopia
²Department of Internal Medicine I, Endocrinology and Metabolism, University of Heidelberg, Heidelberg, Germany

Abstract

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Summary

The effect of the long-acting somatostatin analogue SMS 201-995 on cellular proliferation and calcitonin production was examined in rMTC 6-23 cells. A dose-dependent inhibition of calcitonin release and cellular calcitonin content was obtained in cells exposed to SMS 201-995 for 72 hrs. The dose-dependent antiproliferative effect of SMS 201-995 (10^-8-10^-6M) was significant after 72 hrs of exposure. SMS 201-995 has an inhibitory effect on calcitonin secretion and synthesis as well as on the growth of C-cells.

Key words

SMS 201-995 (Octreot) - Calcitonin - Secretion and Content - C-Cell Line (rMTC 6-23) - Medullary Thyroid Carcinoma (MTC)

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