Increase of Serum Somatomedin C in Hyperthyroid Patients With Pregnancy

S. Suzuki; T. Yamada; T. Shirota; T. Aizawa; M. Ishihara; K. Tomita; K. Kuma; K. Kamoi

doi:10.1055/s-2007-1003260

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1992; 24(2): 78-81
DOI: 10.1055/s-2007-1003260

Clinical

Increase of Serum Somatomedin C in Hyperthyroid Patients With Pregnancy

S. Suzuki¹ , T. Yamada¹ , T. Shirota¹ , T. Aizawa¹ , M. Ishihara¹ , K. Tomita² , K. Kuma³ , K. Kamoi⁴

¹Department of Gerontology, Endocrinology and Metabolism, School of Medicine, Shinshu University, Matsumoto, Naganoken
²Marunouchi Hospital, Matsumoto, Naganoken
³Kuma Thyroid Clinic, Kobe
⁴Department of Medicine, Nagaoka Red Cross Hospital, Nagaoka, Niigataken, Japan

Abstract

PDF Download

Summary

In thyrotoxic women with pregnancy, serum somatomedin C (SmC) concentration was markedly elevated (mean±SD 13.57±4.66 U/ml) compared to thyrotoxic women without pregnancy (1.24±1.09 U/ml), non-pregnant euthyroid women previously treated for hyperthyroidism (0.87±0.30 U/ml), normal subjects with pregnancy (6.08±3.36 U/ml) and pregnant euthyroid women previously treated for hyperthyroidism (5.98±1.52 U/ml). Since SmC/growth hormone ratio was significantly more in thyrotoxic pregnant women than in normal pregnant women and euthyroid pregnant women previously treated for hyperthyroidism, and since human placental lactogen (HPL), human chorionic gonadotropin (HCG) and prolactin (PRL) do not crossreact with SmC antibody, it is suggested that excess thyroid hormone during pregnancy results in excessive hepatic somatomedin C production.

Key words

Hyperthyroidism - Pregnancy - TBG - SomatomedinC - GH

PDF (341 kb)