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Horm Metab Res 1990; 22(8): 405-407
DOI: 10.1055/s-2007-1004934
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© Georg Thieme Verlag, Stuttgart · New York

Spontaneous Diabetes in BB Rats: Evidence for Insulin Dependent Liver Microsomal Δ6 and Δ5 Desaturase Activities

Virginie Mimouni, J.-P. Poisson
  • Laboratoire de Physiologie Animale et de la Nutrition, Faculté des Sciences Mirande, Dijon, France
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Publication History

1989

1990

Publication Date:
14 March 2008 (online)

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Summary

We studied linoleic acid Δ5 and dihomo-γ-linolenic acid Δ5 desaturations, and fatty acid composition, of liver microsomes in the insulin-dependent spontaneously diabetic adult female BB rat. These desaturations were defective along the normo- and hyper-glycemic period and restored during the hypoglycemic period which followed the insulin injection to the diabetic rats. The fatty acid composition of BB rats microsomes was not consistent with the desaturase activities at the different periods of glycemia, probably because other factors than desaturation impairments were involved in the evolution of fatty acid composition.

Key words

Spontaneous Diabetes - BB Rats - Insulin - Δ6 Desaturase - Δ5 Desaturase - Liver - Microsomes - Fatty Acids