Mechanisms of Cell Engraftment During Liver Repopulation with Hepatocyte Transplantation

Sanjeev Gupta; Kuldeep K. Bhargava; Phyllis M. Novikoff

doi:10.1055/s-2007-1007094

Seminars in Liver Disease, Table of Contents

Semin Liver Dis 1999; 19(1): 15-26
DOI: 10.1055/s-2007-1007094

ORIGINAL ARTICLE

Mechanisms of Cell Engraftment During Liver Repopulation with Hepatocyte Transplantation

Sanjeev Gupta¹ , Kuldeep K. Bhargava² , Phyllis M. Novikoff³

¹Marion Bessin Liver Research Center, Cancer Research Center, General Clinical Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
²Nuclear Medicine at Long Island Jewish Medical Center Campus, Albert Einstein College of Medicine, Bronx, New York
³Marion Bessin Liver Research Center, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York

Abstract

ABSTRACT

Hepatocyte transplantation has excited much interest among investigators for applications in cell therapy and studies of fundamental mechanisms concerning liver biology. Progress in these areas has been greatly facilitated by the development of novel animal models. An understanding of early events during engraftment of transplanted cells is essential for optimal repopulation of the liver. Insights into how transplanted cells integrate in the parenchyma of the liver with reconstitution of specific plasma membrane structures is critical in devising therapeutic strategies for specific disorders. Moreover, these insights are necessary for understanding mechanisms concerning regulation of cell proliferation and gene expression in transplanted hepatocytes. Finally, analysis of the safety of cell transplantation is necessary for clinical applications of liver repopulation with cell transplantation. This review highlights selected advances in related areas concerning liver repopulation.

KEY WORDS

hepatocyte - transplantation - liver

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