Human Atrial Natriuretic Polypeptide in Plasma of Patients with Anorexia Nervosa

M. Ohashi; N. Fujio; H. Nawata; K. Kato; S. Matsubayashi; H. Tamai; H. Matsuo; H. Ibayashi

doi:10.1055/s-2007-1010922

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1988; 20(11): 705-708
DOI: 10.1055/s-2007-1010922

Clinical

Human Atrial Natriuretic Polypeptide in Plasma of Patients with Anorexia Nervosa

M. Ohashi¹ , N. Fujio¹ , H. Nawata¹ , K. Kato¹ , S. Matsubayashi² , H. Tamai² , H. Matsuo³ , H. Ibayashi¹

¹Third Department of Internal Medicine, Kyushu University, Faculty of Medicine, Fukuoka, Japan
²Department of Psychosomatic Medicine, Kyushu University, Faculty of Medicine, Fukuoka, Japan
³Second Department of Biochemistry, Miyazaki Medical College, Miyazaki, Japan

Abstract

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Summary

To examine the effects of chronic dehydration and starvation on plasma levels of human atrial natriuretic polypeptide (hANP) in human subjects, the basal level and saline-induced rise of plasma hANP in 7 patients with anorexia nervosa were compared with those in age-matched healthy subjects. The unstimulated level of plasma hANP was markedly high in the patients with anorexia nervosa (patients vs. control; 55.4±9.0 pg/ml vs. 11.4±6.1 pg/ml, P < 0.01). However, no significant increase of plasma hANP in the anorectic patients was observed in response to saline-infusion, while a 3-fold increase over the basal level of plasma hANP was noted in the saline-infused normal young subjects. These results show that hANP may be secreted to an inadequate extent, hence the release would be resistant to volume-loading. The pathophysiological meaning of such a high plasma concentrations of hANP in anorexia nervosa is the subject of ongoing studies.

Key-Words

Weight Loss - RIA - Dehydration - Saline

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