Summary
After immunization with SRBC, the number of plaque-forming cells (PFC) in the spleen
of alloxan-diabetic mice, in nondiabetic TIR mice and in alloxan-diabetic TIR mice
was significantly decreased as compared with control non-diabetic donors. The ability
of lymphocytes from alloxan-diabetic mice to adoptively restore the suppressed immune
response of TIR mice, was reduced in comparison with the effect of lymphocytes from
normal, nondiabetic donors.
Local GVH reaction in nondiabetic rat recipients provoked by lymphocytes from control
healthy mice was 5.6 ± 0.7 mm. Significantly lower rate of local GVH reaction after
injection of lymphocytes from diabetic donors was found in diabetic as in nondiabetic
recipients as well. Treatment of alloxan-diabetic mice with thymus extract or with
insulin, partly restored depressed function of the humoral and cellular system. Treatment
of diabetic mice with both thymus extract and insulin, was even more effective in
restoring of their immune reactivity.
Diabetic condition strongly influenced the function of the immune system. This could
be attributed to depletion of T-lymphocytes, changed relations between the lymphocyte
subpopulations in diabetic donors, and disturbance of lymphocyte metabolism.
Key-Words
Alloxan-Experimental Diabetes
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PFC
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Local GVH
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Thymus Extract
