Summary
In an approach to addressing species specificity of thyroid stimulating antibodies
(TSAb) stimulation of T3 release by Graves' sera was comparatively studied in human
and porcine thyroid slices. A high sensitivity and specificity was found for the T3
bioassay independently on the use of human or porcine thyroid. Moreover, activity
indices of the individual sera in both tissues were significantly correlated to each
other and to circulating hormone levels in untreated disease.
In conclusion, we suppose a lack of functionally relevant differences between target
antigens, brought about probably by the TSH receptor itself and other membrane components,
in human and porcine thyroid. Thus, for clinically applicable T3 releasing bioassay
porcine thyroid may be alternatively used. In addition, this bioassay renders the
advantage of reflecting the activity of disease.
Key-Words
TSAb
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T3
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Species Specificity
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Thyroid Slices
