Furosine, which was formed by acid hydrolysis of fructose-lysine, was determined and
used as an indicator of glycosylated protein. The diabetic patients had significantly
higher fructose-lysine levels in finger nails than healthy subjects [10.8 ± 4.6% (mean
± S.D.) vs 4.2 ± 1.1%]. The best correlation was found between the fructose-lysine
value and the fasting blood glucose level determined 3 to 5 months before sampling
nails in diabetics.
These results suggest that the furosine derived from fructose-lysine in finger nails
may become an indicator of blood glucose control during the past 3 to 5 months in
diabetics.
Furosine
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Fructose-lysine
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Glycosylation
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Diabetes Mellitus
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Nail
