Diagnostic Significance of Endoscopic Biopsy in Crohn's Disease

R. Pötzi; M. Walgram; H. Lochs; H. Holzner; A. Gangl

doi:10.1055/s-2007-1012901

Endoscopy, Table of Contents

Endoscopy 1989; 21(2): 60-62
DOI: 10.1055/s-2007-1012901

Diagnostic Significance of Endoscopic Biopsy in Crohn's Disease

R. Pötzi^* , M. Walgram^* , H. Lochs^* , H. Holzner⁺ , A. Gangl^*

^*1st Department of Gastroenterology and Hepatology
⁺Institute of Pathology, University of Vienna, Austria

This study was presented in part at the World Congress of Gastroenterology, September 1986, Sao Paulo, Brazil (11)

Abstract

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Summary

We investigated the diagnostic value of biopsies taken from Crohn's lesions such as ulcers, aphthoid lesions, cobble-stone epithelium and “pseudopolyps”. One hundred and forty-six colonoscopies performed in 141 patients with Crohn's disease (CD) were analyzed. Biopsies were taken during colonoscopy from different gross lesions. Histologic confirmation of CD by granulomas and microgranulomas was obtained in 36 cases from 146 colonoscopies (24.7 %). In 80 investigations (54.8 %) the histologic findings were consistent with, but not diagnostic of, CD, in 30 cases (20.5 %) histology was non-diagnostic. The lesions most likely to contain granulomas were ulcers and we therefore conclude that biopsies taken from ulcer are diagnostically superior to those taken from other lesions seen in CD.

Key words:

Crohn's disease - Biopsies - Diagnosis - Endoscopy

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