Summary
The 24 hour urinary free cortisol and cortisone excretion after an oral 100 g glucose
load was measured in 60 males (aged 22-56) divided into three groups. G-I consisted
of 10 healthy men, G-II of 37 surgical patients and G-III comprised 23 patients with
atherosclerotic peripheral vascular disease. The followed subjects responded to the
glucose ingestion accordingly to their cortisol excretion. Subjects with an urinary
cortisol excretion up to 200 μg/24 h responded to the glucose load with an increase
of excretion in free cortisol and cortisone. Subjects with the excretion of cortisol
above 200 μg/24 h responded unambiguously with a decrease in their excretion. We suggest
that these changes in both directions can be explained by the available amount of
NADPH in the liver. In patients with atherosclerotic peripheral vascular disease,
in whom disturbances in lipid and carbohydrate metabolism can be proposed, the response
of free corticoids, namely the responde of cortisone, are unequal.
Key-Words:
Urinary Free Cortisol
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Free Cortisone
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Oral Glucose Load
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Metabolism of Cortisol
