Testosterone Metabolic Clearance Rate and Production Rate in the Male Infant Rhesus Monkey

J. D. Booth; J. D. Bacher; D. L. Loriaux; F. G. Cassorla

doi:10.1055/s-2007-1013466

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1985; 17(2): 110-111
DOI: 10.1055/s-2007-1013466

SHORT COMMUNICATIONS

Testosterone Metabolic Clearance Rate and Production Rate in the Male Infant Rhesus Monkey

J. D. Booth, J. D. Bacher, D. L. Loriaux, F. G. Cassorla

Developmental Endocrinology Branch, National Institute of Child Health and Human Development and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland, U.S.A.

Abstract

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Summary

The male infant rhesus monkey (Macaca mulatta) undergoes a period of testicular activation similar to that seen in the human infant. Plasma testosterone (T) concentrations rise after birth, reaching levels of about 500 ng/dl at 1-3 mo of age and then fall to approximately 50 ng/dl at 6 mo. The plasma T metabolic clearance rates (MCR_T) and production rates (PR_T) were measured in two rhesus infants at 1 and 6 mo of age to determine the mechanism of the observed in-crease in plasma T. While there was little change in the MCR_T between 1 and 6 mo, PR_T was much higher at 1 mo than at 6 mo of age. These observations are consistent with the hypothesis that the increased plasma testosterone levels in infant rhesus monkeys reflect an increased production of testosterone rather than an altered metabolic disposition of the hormone.

Key-Words:

Testosterone - Infancy - Metabolic Clearance Rate - Production Rate

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