In 14 hypertensives the effect of captopril (angiotensin-converting enzyme inhibitor)
treatment on red blood cell Na+, K+, Mg2+ and Zn2+ concentrations and on plasma Zn2+ concentrations were studied. Intraerythrocytic Zn2+ concentrations increased slightly, whereas plasma zinc concentrations decreased.
The concurrence of hypozincemia with side effects resembling the symptoms of zinc
deficiency such as loss of smell and taste suggests a role of alterations in zinc
metabolism for the pharmacodynamics of captopril.
Angiotensin Convening Enzyme Inhibitor
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Zinc
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Side Effects
