Summary
Recently hydrazonopropionate derivatives have been recognized as a new group of compounds
with strong hypoglycemic effects in various laboratory animals. The hypoglycemia probably
has several causes of which an inhibition of gluconeogenesis and of intestinal glucose
uptake could be identified.
In the present report, the influence of phenylethylhydrazonopropionate, cyclohexylethylhydrazonopropionate,
methylcinnamylhydrazonopropionate and their corresponding hydrazine derivatives on
the glucose uptake of rat and guinea pig jejunum has been compared with the well known
effects caused by phenformin. All substances tested inhibited the jejunal glucose
uptake, phenelzine, methylcinnamylhydrazine and cyclohexylhydrazonopropionate more
effective, the other compounds less effective than phenformin. The hydrazine derivatives
appeared more effective than the hydrazone compounds used.
The cellular ATP/ADP ratio was not influenced by the hydrazonopropionate compounds.
Key-Words:
Phenylethylhydrazonopropionate
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Cyclohexylethylhydrazonopropionate
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Methylcinnamylhydrazonopropionate
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Jejunal Glucose Absorption
