Depression of thyroid status with thiouracil has been shown to delay the response
of the hypothalamus-pituitaryadrenal axis to stress in young rats. In vivo and in vitro bioassay studies have indicated that the hypothalamus is the main site of axis alteration
in 15 day old animals. The present study has found a significantly depressed hypothalamic
content of immunoassayable corticotropin-releasing factor (CRF) in thiouracil treated
young rats.
Thiouracil
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Corticotropin-Releasing Factor (CRF)
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Radioimmunoassay (RIA)
