Streptozotocin-induced insulin deficient rats allowed to run at will had significantly
(P < 0.001) lower mean (± SEM) plasma glucose levels (12.1 ± 0.9 vs 22.6 ± 1.7 mM/l)
than did equally insulin deficient sedentary rats. Mutscle glycogen phosphorylase
and synthase activities were similar in exercise-trained and sedentary diabetic rats,
and were unchanged fromcontrol values. In contrast, muscle phosphofructokinase activity
was reduced (P < 0.001) in sedentary rates with insulin deficiency, and the defect
was significantly reversed ( P ± 0.01) when such rats were allowed to run spontaneously.
These results are consistent with the view that the ability of exercise-training to
attenuate the magnitude of hyperglycemiain streptozotocin-induced insulin deficiency
is associated with an effect on a key regulatory enzyme in the glycolytic pathway
Exercise Training
-
Insulin-Deficient Diabets
-
Muscle Enzymes
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Muscle Phosphofructokinase Activity
-
Muscle Glycogen Synthase Activity
-
Muscle Phosphorylase Activity
