Summary
The present study was conducted to investigate how the in vivo glucagon secretory
response to 2-deoxy-D-glucose relates to control of nervous system. Plasma glucagon
levels in the rat were significantly elevated by 2-deoxy-D-glucose administration
(40 mg/100 g body weight). That response was suppressed by hexamethonium, a nicotinic
ganglionic blocker. By contrast, treatment with atropine (5 mg/100 g body weight),
a muscarinic antagonist, had no effect on glucagon secretion due to the same dose
of the deoxysugar, whereas the drug totally inhibited the response to a lower concentration
of the deoxysugar. Administration of 2-deoxy-D-glucose significantly elevated plasma
epinephrine levels, and it was suppressed by hexamethonium. Plasma insulin levels
were not so changed despite hyperglycaemia. In conclusion, the present study suggests
that 2-deoxy-D-glucose may act on cholinergic nerve system to stimulate the release
of glucagon and epinephrine.
Key-Words:
Rat
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2-Deoxy-D-Glucose
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Glucagon
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Epinephrine
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Insulin
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Glucose
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Hyperglycaemia
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Atropine
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Hexamethonium
