Summary
In 3 healthy men and 4 healthy women, and in 5 men and 2 women with confirmed chronic
relapsing pancreatitis (CRP) the inhibitory effect of somatostatin on pancreatic exocrine
function and insulin secretion stimulated with pancreozymin and secretin was determined.
In all 7 patients with CRP the volume of pancreatic juice and the bicarbonate and
amylase and protein output after stimulation were lower than in healthy subjects,
and somatostatin had a reduced inhibitory effect on both the basal secretion and particularly
on the pancreozymin-secretin-stimulated secretion. A similarly lower inhibitory effect
of somatostatin on the secretin-pancreozymin induced increase in blood insulin (IRI)
level was observed in these patients.
The presented data suggest that the damaged pancreas reacts less effectively not only
to the stimuli enhancing its exocrine and endocrine secretory activity, but also to
the stimuli inhibiting this activity. This observation may be of practical value for
the evaluation of the functional efficiency of the pancreas.
Key-Words:
Somatostatin
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Secretin
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Pancreozymin
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Serum IRI
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Pancreatic Juice
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Pancreatitis
