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Semin Reprod Med 1999; 17(2): 167-174
DOI: 10.1055/s-2007-1016223
Copyright © 1999 by Thieme Medical Publishers, Inc.

Signaling Pathways and Diabetic Embryopathy

N. Dhanasekaran*, † , Ying-King Wu† , E. Albert Reece†
  • *Fels Institute for Cancer Research and Molecular Biology and
  • †Department of Obstetrics, Gynecology, and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania.
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Publication History

Publication Date:
15 March 2008 (online)

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Abstract

Diabetic embryopathy is the leading cause of neonatal death and/or congenital malformations in infants of diabetic mothers. Because the development of the embryo critically depends on the maternal and the embryonic signaling pathways, a defective signaling mechanism between the maternal and the embryonic tissues appears to be involved in the etiology of diabetic embryopathy. Analyses of the recent studies from different laboratories suggest a “multifactorial” basis for diabetic embryopathy. These studies suggest that a wide variety of signal-transducers converge towards the regulation of elcosanoid signaling pathyway which appears to be the critical pathway involved in diabetic embrhyopathy. The characterization of the regulatory components of this pathway is likely to identify the signaling loci susceptible for the therapeutic intervention.

Keywords:

Diabetic embryopathy - hypoglycemia - Arachidonic Acid - Prostaglandins - ROS - PLA2 - COX-2 - JNK - p38MAPK - ERK - PKC

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