Summary
We have compared the effects of equimolar doses of intravenous somatostatin-28 (SS-28)
and somatostatin-14 (SS-14) (250 μg and 125 μg, respectively) on the secretion of
pancreatic polypeptide (PP), glucagon and insulin evoked by a protein-rich meal in
normal subjects. Both peptides reduced the fasting plasma levels of these hormones
and completely abolished their responses to the alimentary stimulus; in addition,
they caused an early decrease of plasma glucose followed by a hyperglycemic phase.
As compared to SS-14, SS-28 elicited a longer-lasting inhibition of PP and insulin
secretion and displayed greater hypo- and hyperglycemic effects. A somatostatin-like
component, similar to SS-28, has been identified in pancreatic extracts as well as
in peripheral plasma. Thus, it might be hypothesized that this peptide plays a role
in the control of pancreatic hormone release.
Key-Words:
Somatostatin-28
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Somatostatin-14
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Pancreatic Polypeptide
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Glucagon
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Insulin
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Glucose
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Normal Subjects
