The relationship of the net uptake of calcium to insulin secretion by pancreatic islets
isolated from Zucker “fatty” rats and their lean counterparts was studied. Islets
from “fatty” rats secreted 1.5 to 3 times as much insulin as did the lean rat islets
over a glucose concentration range of 0 to 27.7 mM. Over the same glucose concentration
range, calcium accumulation was 2-fold greater in islets from the “fatty” rats than
from the others. Both insulin secretion and calcium uptake were 2 to 3 fold greater
for islets from the “fatty” rats than those from the lean animals over an extracellular
calcium concentration range of up to 5 mEq/L. The data indicate that for islets isolated
from Zucker “fatty” rats insulin hypersecretion in response to glucose and extracellular
calcium is associated with enhanced calcium accumulation.
Calcium
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Insulin Secretion
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Zucker “Fatty” Rats
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Pancreatic Islets
