Although anti-insulin receptor antibodies mimic insulin in many of its actions, antireceptor
antibodies in serum from a diabetic patient did not share the property of insulin
to produce negative cooperativity as defined by the DeMeyts experiment. In contrast, an inhibition of insulin dissociation from IM-9 lymphoblastoid
cells was observed after exposure to the antireceptor antibody. The capacity of this
particular antireceptor antibody to attach to cells whose insulin receptors have been
saturated suggests that the antibody may trap insulin by molecular hindrance.
Insulin Receptor Antibody
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Insulin Dissociation
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Negative Cooperativity
