In 28 male Wistar rats a standardized lung incision was closed by running suture and
in half of the animals by additional application of fibrin adhesive. The animals were
sacrificed 30 minutes and 5 days postoperatively. A significantly higher tolerance
to increased inflation pressure was found in the fibrin-treated group. Ten patients
undergoing pulmonary resection had conventional closure of parenchymatous lesions
with additional fibrin gluing. Under positive air way pressure ventilation the sealing
effect proved to be better after application of fibrin adhesive to the sutured area.
Fibrin adhesive - Lung sutures - Gas-Ieakage
